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KMID : 0357920110450030254
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Korean Journal of Pathology
2011 Volume.45 No. 3 p.254 ~ p.260
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WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study
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Kim Jin-Man
Ko Young-Hyeh
Lee Seung-Sook
Huh Joo-Ryung
Kang Chang-Suk
Kim Chul-Woo
Kang Yun-Kyung
Go Jai-Hyang
Kim Min-Kyung
Kim Wan-Seop
Kim Yoon-Jung
Kim Hyun-Jung
Kim Hee-Kyung
Nam Jong-Hee
Moon Hyung-Bae
Park Chan-Kum
Park Tae-In
Oh Young-Ha
Lee Dong-Wha
Lee Jong-Sil
Lee Ju-Hie
Lee Hye-Kyung
Lim Sung-Chul
Jang Kyu-Yun
Chang Hee-Kyung
Jeon Yoon-Kyung
Jung Hye-Ra
Cho Min-Sun
Cha Hee-Jeong
Choi Suk-Jin
Han Jae-Ho
Hong Sook-Hee
Kim In-Sun
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Abstract
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Background : The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea.
Methods : A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained.
Results : The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was no-dular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed.
Conclusions : Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Wes-tern countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.
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KEYWORD
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Lymphoma, Malignant, WHO, Korea
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